Ulingo lwesigaba sesibini sogonyo lwe-COVID-19 olwenziwe yiAcademy of Military Medical Sciences kunye nenkampani yaseTshayina yebhayoloji iCanSino Biologics ifumanise ukuba ikhuselekile kwaye inokukhuthaza impendulo yokuzikhusela komzimba, ngokophando olupapashwe kwijenali yezonyango iLancet. UMvulo.
Kwakhona ngoMvulo, i-Lancet yapapasha iziphumo zesigaba sokuqala kunye nesigaba-sesibini solingo lwezonyango lwe-adenovirus efanayo yesitofu sokugonya esiphuhliswe zizazinzulu kwiYunivesithi yase-Oxford kunye nenkampani ye-biotech i-AstraZeneca. Olu gonyo lukwabonise impumelelo kukhuseleko kunye namandla ngokuchasene ne-COVID-19.
Iingcali zibize ezi ziphumo "zithembisayo". Nangona kunjalo, imibuzo ecinezelayo ihleli, njengobude bexesha elide lokukhuselwa kwayo, idosi efanelekileyo yokuqalisa impendulo eyomeleleyo ye-immune kwaye ingaba kukho ukungafani okukodwa komkhosi okufana nobudala, isondo okanye ubuhlanga. Le mibuzo iya kuphononongwa kulingo olukhulu lwenqanaba lesithathu lolingo.
Isitofu sokugonya se-adenovirus vectored sisebenza ngokusebenzisa intsholongwane ebandayo ebuthathaka ukwazisa imathiriyeli yemfuzo esuka kwinoveli coronavirus emzimbeni womntu. Umbono kukuqeqesha umzimba ukuba uvelise ii-antibodies eziqaphela iprotein ye-coronavirus spike kwaye uyilwe.
Kulingo lwesigaba sesibini sesitofu sokugonya saseTshayina, abantu abangama-508 bathathe inxaxheba, abangama-253 kubo bafumana idosi ephezulu yesitofu sokugonya, i-129 idosi ephantsi kunye ne-126 i-placebo.
Amashumi alithoba anesihlanu eepesenti abathathi-nxaxheba kwiqela ledosi ephezulu kunye neepesenti ezingama-91 kwiqela ledosi ephantsi babene-T-cell okanye i-antibody immune reactions kwiintsuku ezingama-28 emva kokufumana isitofu sokugonya. Iiseli ze-T zinokujolisa ngokuthe ngqo kwaye zibulale ii-pathogens ezihlaselayo, zizenze zibe yinxalenye ephambili yokuphendula komzimba womntu.
Ababhali bagxininise, nangona kunjalo, ukuba akukho bathathi-nxaxheba baye bavezwa inoveli coronavirus emva kokugonywa, ke kusesekuseni kakhulu ukutsho ukuba umgqatswa wogonyo unokukhusela ngokufanelekileyo kusulelo lwe-COVID-19.
Ngokumalunga neziphumo ezibi, umkhuhlane, ukudinwa kunye neentlungu kwindawo yokutofwa zezinye zeziphumo ebezingalindelekanga eziphawuliweyo zesitofu sokugonya saseTshayina, nangona uninzi lwezi ntshukumo bezinobulali okanye ziphakathi.
Enye i-caveat yayikukuba ngevector yesitofu sokugonya iyintsholongwane ebandayo eqhelekileyo, abantu banokuba nokugonyeka kwangaphambili okubulala umntu ophethe intsholongwane ngaphambi kokuba isitofu sokugonya sisebenze, esinokuthi sithintele ngokuyinxenye iimpendulo zomzimba. Xa kuthelekiswa nabantu abancinci, abathathi-nxaxheba abadala ngokubanzi babeneempendulo ezisezantsi zokhuselo lomzimba, uphando lufumene.
U-Chen Wei, okhokele umsebenzi kwisitofu sokugonya, uthe kwingxelo yeendaba ukuba abantu abadala banokufuna idosi eyongezelelweyo ukuphembelela impendulo eyomeleleyo yomzimba, kodwa uphando olongezelelweyo luya kufuneka ukuvavanya loo ndlela.
UCanSino, umphuhlisi wesitofu sokugonya, usekuthethaneni ngokusungula izilingo zenqanaba lesithathu kumazwe angaphandle, uQiu Dongxu, umlawuli olawulayo kunye nomseki weCanSino, utshilo kwinkomfa yaseSuzhou, kwiphondo laseJiangsu, ngoMgqibelo.
Umhleli okhaphayo kwiThe Lancet kumaphononongo amabini amva nje okugonya abize iziphumo zolingo oluvela e-China nase-United Kingdom “zifana kakhulu kwaye ziyathembisa”.
Ixesha lokuposa: Jul-22-2020