Isivivinyo somtholampilo sesigaba sesibili somuntu ozogomela i-COVID-19 esidalwe yi-Academy of Military Medical Science kanye nenkampani yaseShayina ye-biotech iCanSino Biologics ithole ukuthi iphephile futhi ingadala impendulo yokuzivikela komzimba, ngokocwaningo olushicilelwe kumagazini wezokwelapha i-Lancet on. UMsombuluko.
Futhi ngoMsombuluko, i-Lancet ishicilele imiphumela yokuhlolwa komtholampilo kwesigaba sokuqala kanye nesigaba sesibili somuthi ofanayo wokugomela i-adenovirus vectored owenziwe ososayensi base-Oxford University kanye nenkampani ye-biotech i-AstraZeneca.Lowo mgomo ubuye wakhombisa impumelelo kwezokuphepha kanye namandla okulwa ne-COVID-19.
Ochwepheshe babize le miphumela ngokuthi “iyathembisa”.Kodwa-ke, kusasele imibuzo ecindezelayo, njengobude besikhathi sokuvikela kwayo, umthamo ofanele wokucupha impendulo eqinile yokuzivikela komzimba kanye nokuthi ingabe kunomehluko oqondene nomsingathi onjengobudala, ubulili noma ubuzwe.Le mibuzo izophenywa esikalini esikhulu sesivivinyo sesigaba sesithathu.
Umuthi wokugomela i-adenovirus vectored usebenza ngokusebenzisa igciwane elibandayo elivamile elibuthakathaka ukwethula izinto zofuzo ezivela ku-coronavirus yenoveli emzimbeni womuntu.Umqondo uwukuqeqesha umzimba ukuthi ukhiqize amasosha omzimba abona amaprotheni e-coronavirus spike futhi alwe nawo.
Ocwaningweni lwesigaba sesibili somuthi wokugoma waseShayina, bangu-508 abantu ababambe iqhaza, abangama-253 kubo bathola umthamo omkhulu womuthi wokugoma, abangu-129 umthamo ophansi kanti abangu-126 i-placebo.
Amaphesenti angamashumi ayisishiyagalolunye nanhlanu ababambiqhaza eqenjini lethamo eliphezulu kanye namaphesenti angama-91 eqenjini lethamo eliphansi babe nezimpendulo zokuzivikela ezifweni ze-T-cell noma ze-antibody ezinsukwini ezingama-28 ngemuva kokuthola umgomo.Ama-T-cell angakhomba futhi abulale amagciwane ahlaselayo, awenze abe yingxenye ebalulekile yokusabela komzimba womuntu.
Ababhali bagcizelele, nokho, ukuthi abekho ababambiqhaza abavezwe inoveli coronavirus ngemuva kokugonywa, ngakho-ke kusesekuseni kakhulu ukusho ukuthi lowo ozogomela angakwazi yini ukuvikela ngempumelelo ekuthelelekeni kwe-COVID-19.
Ngokuqondene nokusabela okungekuhle, imfiva, ukukhathala kanye nobuhlungu bendawo yomjovo kwakungeminye yemiphumela emibi ephawuliwe yomuthi wokugoma waseShayina, nakuba iningi lalokhu kusabela lalithambile noma limaphakathi.
Esinye isixwayiso sasiwukuthi njengoba i-vector yomgomo iyigciwane elivamile lomkhuhlane, abantu bangase babe nokuvikeleka okukhona ngaphambili okubulala othwala igciwane ngaphambi kokuba umgomo uqale ukusebenza, okungase kuthikameze kancane ukuphendula kwamasosha omzimba.Uma kuqhathaniswa nabantu abasha, ababambiqhaza asebekhulile ngokuvamile babe nezimpendulo eziphansi kakhulu zokuzivikela komzimba, ucwaningo lwathola.
UChen Wei, obehola umsebenzi wokugomela, uthe esitatimendeni esikhishwe yizindaba ukuthi abantu asebekhulile bangahle badinge umthamo owengeziwe ukuze bathole impendulo eqinile yokuzivikela komzimba, kodwa ucwaningo olwengeziwe luzodingeka ukuze kuhlolwe leyo ndlela.
UCanSino, umthuthukisi womuthi wokugoma, usezingxoxweni zokwethula izivivinyo zesigaba sesithathu emazweni amaningana angaphandle, uQiu Dongxu, umqondisi omkhulu kanye nomsunguli weCanSino, engqungqutheleni ebiseSuzhou, esifundazweni saseJiangsu, ngoMgqibelo.
Isihloko esihambisana naso ku-Lancet ocwaningweni lwakamuva lokugoma lwabiza imiphumela yokuhlolwa okuvela e-China nase-United Kingdom "kufana kakhulu futhi kuyathembisa".
Isikhathi sokuthumela: Jul-22-2020